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Question 1
A surgical short-case slide shows a breast core biopsy with a proliferation of small, regular epithelial cells in a cribriform and solid pattern filling and distending ducts, with no myoepithelial layer demonstrable on p63 immunostaining around the involved spaces but preserved myoepithelium peripherally. There is no stromal invasion. What is the correct FRCPath-level diagnosis?
Correct Answer:
Ductal carcinoma in situ
Question 2
In an FRCPath Part 2 surgical histology short case, a colonic polyp shows serrated crypt architecture with dilatation and lateral (boot-shaped) growth at the crypt base, crypt branching, and no overt cytological dysplasia. Which lesion best fits these features?
Correct Answer:
Sessile serrated lesion
Question 3
A renal core biopsy long case shows diffuse global thickening of glomerular basement membranes with subepithelial 'spikes' on silver stain and granular capillary-loop IgG and C3 on immunofluorescence. PLA2R immunostaining is positive. What is the diagnosis?
Correct Answer:
Membranous nephropathy
Question 4
A soft tissue long case shows a deep thigh tumour with sheets of uniform small round blue cells, a delicate fibrous septal network and strong membranous CD99. FISH demonstrates an EWSR1 gene rearrangement. Which diagnosis is most appropriate?
Correct Answer:
Ewing sarcoma
Question 5
On a surgical short case, a thyroid lobectomy slide shows a well-circumscribed encapsulated follicular-patterned tumour. The nuclei are enlarged, overlapping, with nuclear grooves and occasional pseudoinclusions, but there is no capsular or vascular invasion. What is the most accurate diagnosis to give?
Correct Answer:
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
Question 1
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About this Exam

Prepare with the FRCPath Part 2 Practice Questions - FRCPath Part 2 Examination Exam practice quiz. This question bank includes 100 questions covering shows, cells, case, diagnosis, and tumour. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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FRCPath Part 2 Practice Questions - FRCPath Part 2 Examination Exam

This practice set contains 100 questions from the matching question bank and focuses on shows, cells, case, diagnosis, and tumour. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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