Question 1
A 62-year-old man with a 40 pack-year smoking history has a hilar lung mass biopsied. Histology shows nests of cells with keratin pearls and intercellular bridges. Which is the most likely diagnosis?
Correct Answer:
Squamous cell carcinoma
Question 2
A colonic adenocarcinoma resection is being reported using the RCPath dataset. Which feature is the single most important determinant of the pT stage?
Correct Answer:
Depth of invasion through the bowel wall
Question 3
Immunohistochemistry on a poorly differentiated metastatic carcinoma of unknown primary shows CK7-positive, CK20-negative, TTF-1-positive staining. Which primary site is most likely?
Correct Answer:
Lung
Question 4
Which immunohistochemical marker is most useful for confirming a diagnosis of gastrointestinal stromal tumour (GIST)?
Correct Answer:
DOG1 (and CD117/KIT)
Question 5
A breast core biopsy shows invasive carcinoma. Which combination of biomarkers determines whether the patient is offered anti-HER2 therapy and endocrine therapy?
Correct Answer:
ER, PR and HER2
Question 1
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Prepare with the FRCPath Part 1 Practice Questions - FRCPath Part 1 Examination Exam practice quiz. This question bank includes 100 questions covering shows, patient, diagnosis, blood, and cells. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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FRCPath Part 1 Practice Questions - FRCPath Part 1 Examination Exam

This practice set contains 100 questions from the matching question bank and focuses on shows, patient, diagnosis, blood, and cells. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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