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Question 1
A 72-year-old male presents with exertional dyspnea and a harsh, crescendo-decrescendo systolic murmur best heard at the right upper sternal border. Which of the following physical exam findings would be most consistent with severe aortic stenosis?
Correct Answer:
A low-amplitude and delayed carotid upstroke
Question 2
A 55-year-old male with a history of ST-elevation myocardial infarction (STEMI) is being discharged. In addition to aspirin and a P2Y12 inhibitor, which of the following medication classes provides a mortality benefit and should be initiated prior to discharge for secondary prevention?
Correct Answer:
Beta-blockers
Question 3
A 68-year-old female is diagnosed with multiple myeloma. Her initial lab work shows a hemoglobin of 9.2 g/dL, serum creatinine of 2.5 mg/dL, and serum calcium of 12.1 mg/dL. An X-ray reveals multiple lytic lesions in the vertebrae. Which of these findings is NOT part of the classic CRAB criteria for diagnosing symptomatic multiple myeloma?
Correct Answer:
Thrombocytosis (Platelets > 450,000/µL)
Question 4
A patient is hospitalized and receives unfractionated heparin for a deep vein thrombosis. Five days later, their platelet count drops from 250,000/µL to 90,000/µL, and a new pulmonary embolism is suspected. What is the most likely underlying pathophysiology of this condition?
Correct Answer:
Autoantibody formation against the heparin-platelet factor 4 (PF4) complex
Question 5
A 22-year-old male of Mediterranean descent presents with fatigue, jaundice, and dark urine after being treated with a sulfonamide antibiotic for a urinary tract infection. A complete blood count reveals normocytic anemia, and a peripheral smear shows Heinz bodies and bite cells. This presentation is most characteristic of a deficiency in which of the following enzymes?
Correct Answer:
Glucose-6-phosphate dehydrogenase
Question 1
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About this Exam

Prepare with the COMSAE Comprehensive Osteopathic Medical Self-Assessment Exam practice quiz. This question bank includes 117 questions covering year-old, presents, patient, osteopathic, and male. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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COMSAE Comprehensive Osteopathic Medical Self-Assessment Exam

This practice set contains 117 questions from the matching question bank and focuses on year-old, presents, patient, osteopathic, and male. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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