Certified Pediatric Hematology Oncology Nurse (CPHON)

Question 1

A pediatric patient undergoing allogeneic hematopoietic stem cell transplant (HSCT) develops a skin rash, diarrhea, and elevated bilirubin 3 weeks post-transplant. The nurse recognizes this as which complication?

Acute graft-versus-host disease (aGVHD) Engraftment syndrome Veno-occlusive disease Cytomegalovirus colitis

Correct Answer:

Acute graft-versus-host disease (aGVHD)

Question 2

Which conditioning regimen used prior to HSCT is associated with the highest risk of veno-occlusive disease (VOD)/sinusoidal obstruction syndrome?

Myeloablative conditioning with busulfan and cyclophosphamide Reduced intensity conditioning with fludarabine Non-myeloablative conditioning Standard chemotherapy without radiation

Correct Answer:

Myeloablative conditioning with busulfan and cyclophosphamide

Question 3

What is the primary purpose of the preparative (conditioning) regimen given before HSCT?

To eradicate residual malignancy and create marrow space for donor cells To prevent graft-versus-host disease To stimulate stem cell mobilization in the donor To induce remission from active disease

Correct Answer:

To eradicate residual malignancy and create marrow space for donor cells

Question 4

A child 6 months post-allogeneic HSCT develops dry eyes, oral mucosal changes, joint contractures, and skin tightening. This clinical picture is most consistent with:

Chronic graft-versus-host disease (cGVHD) Late cytomegalovirus end-organ disease Post-transplant lymphoproliferative disorder Drug-induced scleroderma

Correct Answer:

Chronic graft-versus-host disease (cGVHD)

Question 5

What is engraftment, and what laboratory finding confirms that it has occurred following HSCT?

Recovery of donor-derived hematopoiesis, confirmed by absolute neutrophil count (ANC) ≥500/µL for 3 consecutive days Disappearance of GVHD symptoms Platelet count above 100,000/µL Return of pre-transplant immunoglobulin levels

Correct Answer:

Recovery of donor-derived hematopoiesis, confirmed by absolute neutrophil count (ANC) ≥500/µL for 3 consecutive days

Exam overview

About this Exam

Prepare with the Certified Pediatric Hematology Oncology Nurse (CPHON) practice quiz. This question bank includes 30 questions covering nurse, child, patient, develops, and chemotherapy. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

More details

Additional Information

Certified Pediatric Hematology Oncology Nurse (CPHON)

This practice set contains 30 questions from the matching question bank and focuses on nurse, child, patient, develops, and chemotherapy. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

Quiz information

Frequently Asked Questions

The complete question count is available after full access is unlocked.

No fixed duration is currently configured for this quiz.

Question explanations are included where they are available in the quiz content, helping you review the reasoning after answering.

Yes. You can retake the practice test again as you continue studying during your available access period.

After your access is confirmed, you can continue into the complete practice exam from this quiz flow.

Unless explicitly stated otherwise, this page provides independent practice material for study and exam preparation and is not the official examination itself.

Correct Answer:

Correct Answer:

Correct Answer:

Correct Answer:

Correct Answer:

About this Exam

Additional Information

Certified Pediatric Hematology Oncology Nurse (CPHON)

Frequently Asked Questions

Related Questions

ISC2 Certified in Cybersecurity Practice Exam

Aquifer Pediatrics Practice Exam Study Guide

Arizona CNA Certified Nursing Assistant Practice Exam

Certified Professional Public Buyer (CPPB) Practice Exam

Certified Specialist Business Intelligence (CSBI) Practice Test

Certified Specialist In Renal Nutrition (CSR) Practice Exam