Question 1
Which of the following base pairs is held together by three hydrogen bonds in canonical Watson-Crick double-stranded DNA?
Correct Answer:
Guanine-Cytosine
Question 2
What is the approximate size of the human haploid nuclear genome?
Correct Answer:
3 gigabases
Question 3
A pathology resident asks why mitochondrial DNA testing for MELAS (m.3243A>G) requires evaluation of multiple tissue types. Which property of mitochondrial DNA best explains this?
Correct Answer:
Heteroplasmy levels vary between tissues and over time
Question 4
A 4-year-old with severe hypotonia, hyperphagia, and obesity is suspected to have Prader-Willi syndrome. Which mechanism most commonly causes Prader-Willi syndrome?
Correct Answer:
Paternal deletion of 15q11-q13
Question 5
Loss of which mismatch repair protein is most commonly associated with sporadic colorectal cancers exhibiting microsatellite instability?
Correct Answer:
MLH1 (via promoter hypermethylation)
Question 1
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Prepare with the ABPath Molecular Genetic Pathology Practice Questions - American Board of Pathology Molecular Genetic Pathology Subspecialty Certification Examination Exam practice quiz. This question bank includes 100 questions covering variant, commonly, clinical, disease, and acmg. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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ABPath Molecular Genetic Pathology Practice Questions - American Board of Pathology Molecular Genetic Pathology Subspecialty Certification Examination Exam

This practice set contains 100 questions from the matching question bank and focuses on variant, commonly, clinical, disease, and acmg. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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