Question 1
A 65-year-old man presents with bruising and bleeding. Peripheral smear shows hypergranular promyelocytes with Auer rods (some faggot cells). Cytogenetics show t(15;17)(q24;q21). The most likely diagnosis is:
Correct Answer:
Acute promyelocytic leukemia (APL) with PML-RARA
Question 2
A 30-year-old woman presents with fatigue. CBC shows WBC 45,000/μL with neutrophilia, basophilia, and left shift with blasts
Correct Answer:
Chronic myeloid leukemia (CML), chronic phase
Question 3
Peripheral blood flow cytometry in a 70-year-old with lymphocytosis (ALC 15,000/μL) shows a B-cell clone with CD19+, CD5+, CD23+, CD20 dim, FMC7-, surface kappa dim. The diagnosis is:
Correct Answer:
Chronic lymphocytic leukemia (CLL) — because the absolute monoclonal B-cell count is ≥5,000/μL per iwCLL 2018 criteria
Question 4
A lymph node flow on a 62-year-old man shows a B-cell clone with CD19+, CD5+, CD23-, CD20 bright, FMC7+, kappa restriction. IHC shows cyclin D1+ and SOX11+. The most likely diagnosis is:
Correct Answer:
Mantle cell lymphoma (MCL)
Question 5
A lymph node shows follicular architecture with tightly packed, small follicles containing centrocytes and centroblasts. Flow: CD19+/CD10+/BCL6+/BCL2+/CD5-. Cytogenetics: t(14;18)(q32;q21). The diagnosis is:
Correct Answer:
Follicular lymphoma (FL)
Question 1
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Prepare with the ABPath Hematopathology Practice Questions - ABPath Hematopathology Subspecialty Certification Exam practice quiz. This question bank includes 100 questions covering shows, diagnosis, year-old, cells, and marrow. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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ABPath Hematopathology Practice Questions - ABPath Hematopathology Subspecialty Certification Exam

This practice set contains 100 questions from the matching question bank and focuses on shows, diagnosis, year-old, cells, and marrow. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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