The exam required for graduates of osteopathic medicine to obtain a license is COMLEX-USA. This licensing assessment is specifically designed for osteopathic physicians and is administered by the NBOME. It covers the knowledge and clinical skills DOs need to practice, typically across multiple parts that evaluate medical knowledge, clinical reasoning, and patient management within an osteopathic framework. In contrast, the United States Medical Licensing Examination (USMLE) is the licensing path most commonly used by allopathic (MD) graduates, and is not the standard route for DO licensure. The Medical College Admission Test (MCAT) is for medical school admission, not licensure, and the Council on Podiatric Medical Education (CPME) pertains to podiatry, not osteopathic medicine. Some states may recognize USMLE for DO licensure in certain circumstances, but COMLEX-USA is the exam specifically tied to osteopathic licensure.