SOBRAFO Farmácia Oncológica Practice Questions - Título de Especialista em Farmácia Oncológica (SOBRAFO CFF) Exam - SOBRAFO Farmácia Oncológica Practice Questions - Título de Especialista em Farmácia Oncológica (SOBRAFO CFF) Exam

Question 1

Under ANVISA RDC nº 220/2004 (Regulamento Técnico de Serviços de Terapia Antineoplásica), read together with the sterile-compounding requirements of RDC nº 67/2007 Anexo IV, which international cleanroom ISO classification applies to the inner work zone of the Biological Safety Cabinet (primary engineering control) and to the surrounding cleanroom preparation area (secondary engineering control), respectively?

ISO Class 5 (Grade A) inside the Biological Safety Cabinet and ISO Class 7 (Grade B/C) for the surrounding preparation cleanroom. ISO Class 7 inside the Biological Safety Cabinet and ISO Class 8 for the surrounding preparation cleanroom. ISO Class 4 inside the Biological Safety Cabinet and ISO Class 5 for the surrounding preparation cleanroom. ISO Class 8 inside the Biological Safety Cabinet and unclassified controlled air for the surrounding preparation cleanroom.

Correct Answer:

ISO Class 5 (Grade A) inside the Biological Safety Cabinet and ISO Class 7 (Grade B/C) for the surrounding preparation cleanroom.

Question 2

In accordance with ANVISA RDC nº 220/2004, what is the mandatory air pressure differential relationship between the antineoplastic preparation room (cleanroom) and its adjacent ante-room/staging area?

The antineoplastic preparation room must maintain negative differential pressure (-5 to -15 Pa) relative to the adjacent ante-room to contain hazardous aerosols. The antineoplastic preparation room must maintain positive differential pressure (+15 to +30 Pa) relative to the ante-room to prevent particulate entry. The antineoplastic preparation room and the ante-room must be maintained at equal atmospheric pressure (neutral differential pressure). The antineoplastic preparation room must have variable positive-negative cycling pressure controlled by manual dampers.

Correct Answer:

The antineoplastic preparation room must maintain negative differential pressure (-5 to -15 Pa) relative to the adjacent ante-room to contain hazardous aerosols.

Question 3

Which type of Biological Safety Cabinet (BSC / CSB) is defined as providing 100% total external exhaust of air through dedicated HEPA filtration with zero internal recirculation, making it ideal for compounding volatile hazardous antineoplastics?

Class II Type B2 Biological Safety Cabinet Class II Type A2 Biological Safety Cabinet Class I Biological Safety Cabinet Horizontal Laminar Flow Clean Bench

Correct Answer:

Class II Type B2 Biological Safety Cabinet

Question 4

What is the primary technological mechanism by which Closed System Drug Transfer Devices (CSTDs) minimize occupational exposure during antineoplastic reconstitution and administration?

They mechanically prohibit the transfer of environmental contaminants into the system and prevent the escape of hazardous drug or vapor concentrations outside the system. They chemically neutralize cytotoxic functional groups through reactive internal membrane filters upon fluid contact. They utilize ultraviolet germicidal irradiation within the luer-lock connection to destroy chemical bonds. They increase infusion line pressure to accelerate drug delivery time and minimize exposure duration.

Correct Answer:

They mechanically prohibit the transfer of environmental contaminants into the system and prevent the escape of hazardous drug or vapor concentrations outside the system.

Question 5

According to biosafety standards and RDC nº 220/2004, what is the proper protocol for Personal Protective Equipment (PPE) gloving when compounding hazardous antineoplastic medications?

Double gloving with chemotherapy-tested, powder-free gloves (nitrile or neoprene), with the inner glove worn under the gown cuff and the outer glove worn over the gown cuff. Single gloving with standard medical-grade powdered latex gloves pulled firmly over the gown cuff. Double gloving with standard surgical latex gloves, both worn tucked completely underneath the elastic gown cuff. Wearing a single heavy-duty rubber utility glove on the non-dominant hand and no glove on the dominant hand to preserve tactile dexterity.

Correct Answer:

Double gloving with chemotherapy-tested, powder-free gloves (nitrile or neoprene), with the inner glove worn under the gown cuff and the outer glove worn over the gown cuff.

Question 1

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Prepare with the SOBRAFO Farmácia Oncológica Practice Questions - Título de Especialista em Farmácia Oncológica (SOBRAFO CFF) Exam practice quiz. This question bank includes 100 questions covering antineoplastic, compounding, mandatory, safety, and pharmacy. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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SOBRAFO Farmácia Oncológica Practice Questions - Título de Especialista em Farmácia Oncológica (SOBRAFO CFF) Exam

This practice set contains 100 questions from the matching question bank and focuses on antineoplastic, compounding, mandatory, safety, and pharmacy. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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SOBRAFO Farmácia Oncológica Practice Questions - Título de Especialista em Farmácia Oncológica (SOBRAFO CFF) Exam

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