Question 1
A researcher studying long-term potentiation (LTP) in the hippocampus removes magnesium from the extracellular medium and observes enhanced calcium influx at a particular glutamate receptor even at resting membrane potential. Which receptor is responsible for this magnesium-dependent, voltage-gated behaviour?
Correct Answer:
NMDA receptor
Question 2
Which of the following is the primary degradative enzyme for dopamine in the synaptic cleft and is the target of selegiline?
Correct Answer:
Monoamine oxidase B (MAO-B)
Question 3
A patient with Korsakoff syndrome shows profound anterograde amnesia. Damage to which paired structures, classically associated with thiamine deficiency, best accounts for this presentation?
Correct Answer:
Mammillary bodies and mediodorsal thalamic nuclei
Question 4
Which neuroimaging technique relies on the differential magnetic properties of oxygenated versus deoxygenated haemoglobin to infer regional neural activity?
Correct Answer:
Blood-oxygen-level-dependent functional MRI (BOLD fMRI)
Question 5
A 70-year-old man develops a resting tremor, bradykinesia and rigidity. Post-mortem the substantia nigra pars compacta shows depigmentation and intracytoplasmic eosinophilic inclusions. These inclusions are principally composed of which protein?
Correct Answer:
Alpha-synuclein
Question 1
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Prepare with the MRCPsych Paper A Practice Questions - MRCPsych Paper A Exam practice quiz. This question bank includes 100 questions covering patient, behaviour, develops, receptor, and shows. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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MRCPsych Paper A Practice Questions - MRCPsych Paper A Exam

This practice set contains 100 questions from the matching question bank and focuses on patient, behaviour, develops, receptor, and shows. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

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