Internat Pharmacie (Côte d'Ivoire) Practice Questions - Concours National d'Internat en Pharmacie (Côte d'Ivoire) Exam - Internat Pharmacie (Côte d'Ivoire) Practice Questions - Concours National d'Internat en Pharmacie (Côte d'Ivoire) Exam

Question 1

A complete blood count (CBC / NFS) of an anemic patient (Hb 7.8 g/dL) reveals: Mean Corpuscular Volume (MCV) 92 fL, Mean Corpuscular Hemoglobin (MCH) 30 pg, and an absolute reticulocyte count of 220,000/μL (regenerative index >2%). What is the physiological classification of this anemia?

Normocytic normochromic regenerative anemia (e.g., acute hemorrhage or acute hemolysis) Microcytic hypochromic non-regenerative anemia (e.g., iron deficiency) Macrocytic megaloblastic non-regenerative anemia (e.g., vitamin B12 deficiency) Normocytic normochromic aregenerative anemia (e.g., bone marrow aplasia or chronic renal failure)

Correct Answer:

Normocytic normochromic regenerative anemia (e.g., acute hemorrhage or acute hemolysis)

Question 2

In the laboratory differential diagnosis of microcytic hypochromic anemia (MCV

Iron deficiency anemia shows low serum ferritin (<15–30 μg/L) and elevated Total Iron-Binding Capacity (TIBC), whereas anemia of chronic disease shows normal/elevated ferritin and normal/low TIBC Iron deficiency shows high serum ferritin (>300 μg/L) and low soluble transferrin receptors Anemia of chronic disease shows low serum ferritin and elevated transferrin saturation (>50%) Both conditions show high serum iron and high transferrin saturation

Correct Answer:

Iron deficiency anemia shows low serum ferritin (<15–30 μg/L) and elevated Total Iron-Binding Capacity (TIBC), whereas anemia of chronic disease shows normal/elevated ferritin and normal/low TIBC

Question 3

Which combination of biological laboratory findings is pathognomonic for intravascular hemolytic anemia?

Collapsed (undetectable) serum haptoglobin, elevated serum unconjugated bilirubin, elevated serum lactate dehydrogenase (LDH), reticulocytosis, and hemoglobinuria Elevated serum haptoglobin, elevated direct conjugated bilirubin, and low LDH Elevated serum ferritin, normal haptoglobin, and severe reticulocytopenia Isolated elevation of alkaline phosphatase (ALP) with normal bilirubin and normal haptoglobin

Correct Answer:

Collapsed (undetectable) serum haptoglobin, elevated serum unconjugated bilirubin, elevated serum lactate dehydrogenase (LDH), reticulocytosis, and hemoglobinuria

Question 4

A peripheral blood smear and bone marrow aspirate in a 45-year-old patient show 40% blast cells with folded nuclei, granular cytoplasm containing crystalline Auer rods, and intense positivity for Myeloperoxidase (MPO) and Sudan Black B on cytochemical staining. What is the diagnosis?

Acute Myeloid Leukemia (AML / Leucémie Aiguë Myéloblastique) Acute Lymphoblastic Leukemia (ALL / B-ALL) Chronic Lymphocytic Leukemia (CLL / LLC) Multiple Myeloma (Myélome multiple)

Correct Answer:

Acute Myeloid Leukemia (AML / Leucémie Aiguë Myéloblastique)

Question 5

What is the hallmark reciprocal chromosomal translocation and resulting fusion oncogene diagnostic of Chronic Myeloid Leukemia (CML / LMC), which serves as the therapeutic target for tyrosine kinase inhibitors (e.g., imatinib)?

t(9;22)(q34;q11) translocation creating the BCR-ABL1 fusion gene on the Philadelphia (Ph) chromosome t(15;17)(q22;q12) translocation creating the PML-RARA fusion gene t(8;14)(q24;q32) translocation involving the c-MYC and IgH genes t(11;14)(q13;q32) translocation creating the CCND1-IgH fusion gene

Correct Answer:

t(9;22)(q34;q11) translocation creating the BCR-ABL1 fusion gene on the Philadelphia (Ph) chromosome

Question 1

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Internat Pharmacie (Côte d'Ivoire) Practice Questions - Concours National d'Internat en Pharmacie (Côte d'Ivoire) Exam

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