DipHIV Practice Questions - Diploma in HIV Medicine Exam - DipHIV Practice Questions

Question 1

A 34-year-old man recently diagnosed with HIV-1 infection is undergoing baseline evaluation prior to commencing antiretroviral therapy (ART). The clinical team is considering a regimen containing abacavir. Which genetic screening test must be confirmed negative prior to prescribing abacavir?

HLA-B*5701 allele screening HLA-B*2701 allele screening Glucose-6-phosphate dehydrogenase (G6PD) deficiency assay Thiopurine S-methyltransferase (TPMT) activity assay

Correct Answer:

HLA-B*5701 allele screening

Question 2

A 28-year-old woman starts first-line ART with co-formulated bictegravir/tenofovir alafenamide/emtricitabine (Biktarvy). What is the mechanism of action of bictegravir?

Inhibition of HIV-1 integrase strand transfer activity Competitive inhibition of reverse transcriptase nucleotide binding Non-competitive allosteric inhibition of reverse transcriptase Inhibition of HIV-1 protease catalytic cleavage site

Correct Answer:

Inhibition of HIV-1 integrase strand transfer activity

Question 3

A 52-year-old male with HIV-1 infection and baseline eGFR of 55 mL/min/1.73m2 and early osteopenia is being switched from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF). What pharmacokinetic characteristic of TAF accounts for its improved renal and bone safety profile compared to TDF?

TAF is more stable in plasma, delivering active drug intracellularly and resulting in 90% lower systemic plasma tenofovir exposure TAF is cleared exclusively by hepatic metabolism with no renal excretion TAF achieves higher plasma concentrations, which enhances renal tubular clearance TAF does not require intracellular phosphorylation to form active tenofovir diphosphate

Correct Answer:

TAF is more stable in plasma, delivering active drug intracellularly and resulting in 90% lower systemic plasma tenofovir exposure

Question 4

A healthcare assistant sustains a deep needle-stick injury while drawing blood from an HIV-positive patient whose most recent viral load was 45,000 copies/mL. Which statement correctly reflects UK guidelines (BHIVA/BASHH) regarding Post-Exposure Prophylaxis (PEP)?

PEP should be initiated as soon as possible, ideally within 2 hours and no later than 72 hours post-exposure, for a duration of 28 days PEP should be delayed until 14 days after exposure to allow antibody seroconversion testing PEP consists of a 7-day course of zidovudine monotherapy PEP is only indicated if the source patient has a viral load greater than 500,000 copies/mL

Correct Answer:

PEP should be initiated as soon as possible, ideally within 2 hours and no later than 72 hours post-exposure, for a duration of 28 days

Question 5

A 29-year-old cisgender man who has sex with men (MSM) presents for advice on HIV Pre-Exposure Prophylaxis (PrEP). He has episodic sexual exposures and requests event-driven (2-1-1) PrEP with oral TDF/FTC. How should this regimen be taken relative to sex?

Take 2 tablets 2-24 hours before sex, 1 tablet 24 hours after the first dose, and 1 tablet 48 hours after the first dose Take 1 tablet daily starting 7 days before anticipated sexual activity Take 2 tablets immediately after sex and 2 tablets 12 hours later Take 1 tablet every 12 hours for 5 days following sexual exposure

Correct Answer:

Take 2 tablets 2-24 hours before sex, 1 tablet 24 hours after the first dose, and 1 tablet 48 hours after the first dose

Question 1

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Prepare with the DipHIV Practice Questions - Diploma in HIV Medicine Exam practice quiz. This question bank includes 100 questions covering year-old, patient, cells, count, and presents. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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DipHIV Practice Questions - Diploma in HIV Medicine Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, patient, cells, count, and presents. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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DipHIV Practice Questions - Diploma in HIV Medicine Exam

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