BCPS Practice Questions - Board Certified Pharmacotherapy Specialist Exam

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A patient with FULMINANT Clostridioides difficile infection (hypotension, ileus, and toxic megacolon) is not improving on standard oral vancomycin. What is the most appropriate regimen?

Switch to oral metronidazole monotherapy Oral vancomycin 500 mg every 6 hours PLUS IV metronidazole Stop antibiotics and observe Single dose of oral fidaxomicin only

Correct Answer:

Oral vancomycin 500 mg every 6 hours PLUS IV metronidazole

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