CPHON Chemotherapy Practice Test

Which symptom is least typical as a presenting sign of childhood leukemia?

Bone pain Pallor Bleeding Jaundice

Correct Answer:

Jaundice

Explanation:

Leukemia in children most often presents with signs of bone marrow failure and infiltration, so symptoms like bone pain from marrow expansion, pallor from anemia, and bleeding or easy bruising from low platelets are common initial clues. Jaundice, however, points to liver involvement or hemolysis, which is not a typical presenting feature of childhood leukemia. While jaundice can occur if the liver is affected or if there are other concurrent issues, it is not the usual first sign the disease presents with.

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