ASCP International (ASCPi) Practice Exam

In steam sterilization, the key is achieving a high enough temperature with pressurized steam for an adequate exposure time. A standard autoclave runs at about 15 psi, which brings the temperature to roughly 121°C, and holding that heat for about 15 minutes is a well-established parameter to achieve sterility for typical loads. So describing a cycle with 15 psi for 15 minutes matches what is routinely used for steam sterilization. Ethylene oxide is a different sterilization method and not used with steam autoclaves. A maximum temperature of 100°C would not reach the necessary 121°C in a standard autoclave. Dry heat for 20 minutes is another separate method, involving dry heat rather than steam. Therefore, the statement about 15 psi for 15 minutes best describes a valid steam sterilization parameter.