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Blood-Brain Barrier And Cerebral Perfusion Practice Test

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The tight junctions of the BBB are formed by which cells?
Correct Answer:
Capillary endothelial cells
Explanation:
The barrier tight junctions are created by the capillary endothelial cells that line brain microvessels. These endothelial cells form the actual seal between adjacent vessels, giving the blood-brain barrier its characteristic low paracellular permeability. Astrocyte end-feet support and help regulate the barrier by signaling to endothelial cells and contributing to the surrounding basement membrane, but the tight junctions themselves are formed by the endothelial cells. Oligodendrocyte processes make myelin, not barrier junctions, and meningeal fibroblasts reside in the meninges rather than the brain capillaries.

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