Pharmacology IV – Headache Therapeutics Practice Test

Which statement best describes riboflavin therapy in migraine prevention?

It is associated with frequent severe adverse effects. It is expensive and not preferred. It is well tolerated. It is contraindicated in migraine.

Correct Answer:

It is well tolerated.

Explanation:

Riboflavin therapy for migraine prevention is characterized by a favorable safety profile and good tolerability. When given in high daily doses (around 400 mg), it is generally well tolerated with few and mild adverse effects. The most common notable effect is harmless yellow-orange urine from excreted vitamin B2; occasional mild GI upset can occur, but serious adverse effects are rare. Its safety, low risk of interactions, and low cost contribute to it being a preferred preventive option for many patients. This makes the statement that it is well tolerated the best description.

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