ABOG Gynecologic Oncology Practice Questions - ABOG Gynecologic Oncology Subspecialty Qualifying Examination Exam

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The 2023 FIGO endometrial cancer staging incorporates molecular classification (POLEmut, MMRd/MSI-H, p53abn, NSMP). Which molecular subtype has the BEST prognosis?

p53 abnormal (p53abn) POLE ultramutated (POLEmut) — excellent prognosis; typically Stage I even with grade 3 or LVSI MMRd (mismatch repair deficient) NSMP (no specific molecular profile)

Correct Answer:

POLE ultramutated (POLEmut) — excellent prognosis; typically Stage I even with grade 3 or LVSI

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