Urinalysis – Physical And Biochemical Practice Test

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Which statement about crystal polarization is true?
Correct Answer:
Uric acid crystals polarize; cystine crystals do not
Explanation:
Polarized light microscopy tests whether crystals are birefringent, meaning they split light into two rays and show color changes as you rotate the stage. Uric acid crystals have a crystal structure that makes them birefringent, so they polarize under polarized light and display the characteristic color changes. Cystine crystals, by contrast, do not exhibit birefringence under the same conditions, so they do not polarize. This difference helps clinicians distinguish uric acid crystals from cystine crystals in urine sediment.

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