Pharmacology CMS Practice Test

Which statement about Buspirone is true?

It is a benzodiazepine. It binds to serotonin and dopamine receptors. It has rapid onset within 24 hours. It should be avoided with food.

Correct Answer:

It binds to serotonin and dopamine receptors.

Explanation:

Buspirone works through a serotonergic mechanism with some dopaminergic activity, which is why this statement is true. It acts mainly as a partial agonist at 5-HT1A receptors (a serotonin receptor) and also interacts with dopamine receptors, giving it a distinct profile from benzodiazepines. This explains why it doesn’t provide the rapid relief seen with benzodiazepines—effects build up over several days to weeks with consistent dosing. It is not a benzodiazepine, and it can be taken with or without food, so there’s no need to avoid eating with it.

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