Certified Specialist In Obesity And Weight Management (CSOWM) Practice Exam

Which adverse effect on metformin led to switching to glyburide in this case?

Weight gain Hypoglycemia Diarrhea Hypertension

Correct Answer:

Diarrhea

Explanation:

Metformin often causes gastrointestinal side effects, with diarrhea being one of the most common and dose-limiting issues. When diarrhea is persistent or severe, it can make continuing metformin intolerable, prompting a switch to another agent such as glyburide. Other options don’t fit as well: metformin isn’t typically associated with weight gain (it’s usually weight-neutral or may cause weight loss), hypoglycemia is not a common direct result of metformin (though it can occur with other drugs that are added), and hypertension isn’t tied to metformin’s adverse effects.

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