Antibacterials (ABX) Practice Exam

Which option best describes the use of cefiderocol?

Very resistant Gram-negative pathogens Very resistant Gram-positive pathogens Moderate Gram-negative pathogens Fungal pathogens

Correct Answer:

Very resistant Gram-negative pathogens

Explanation:

Cefiderocol is built to tackle the toughest Gram-negative infections. Its unique siderophore “Trojan horse” approach helps the drug slip into Gram-negative bacteria by hijacking iron transport systems, while its stability to many beta-lactamases lets it resist breakdown by enzymes like ESBLs and many carbapenemases. Because of this design, it’s particularly effective against very resistant Gram-negative pathogens such as Pseudomonas, Acinetobacter, and Enterobacterales that produce multiple resistance mechanisms. It does not target Gram-positive bacteria or fungal pathogens, and its strongest justification is for difficult, highly resistant Gram-negative infections rather than moderate ones or non-GN organisms.

Access more questions from this quiz

Continue to Antibacterials (ABX) Practice Exam for more practice questions and the full quiz experience.

Access More Questions