Pharmacology Practice Test

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Which of the following statements most accurately describes the mechanism of action of acyclovir in treating a herpes simplex virus (HSV) infection?

It acts as a neuraminidase inhibitor, preventing the release of newly formed virions from the host cell. It directly inhibits the fusion of the viral envelope with the host cell membrane. It prevents the uncoating of the viral genome after it enters the host cell. It is a guanosine analog that, after phosphorylation by viral thymidine kinase, inhibits viral DNA polymerase and causes chain termination.

Correct Answer:

It is a guanosine analog that, after phosphorylation by viral thymidine kinase, inhibits viral DNA polymerase and causes chain termination.

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