BIPC Substance Abuse And Disorders Practice Exam

Which of the following is NOT a metabolite of diazepam?

Nordiazepam Oxazepam Temazepam Lorazepam

Correct Answer:

Lorazepam

Explanation:

Diazepam is processed by the liver into several metabolites that themselves contribute to its overall effects. The usual metabolic pathway produces nordiazepam, temazepam, and oxazepam, all of which are active and can prolong sedation as diazepam is cleared from the body. Lorazepam, however, is not formed from diazepam’s metabolism; it is a separate benzodiazepine with its own distinct metabolic route, typically undergoing direct glucuronidation rather than oxidative metabolism. So lorazepam is not a metabolite of diazepam.

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