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Step 2 CK First Aid Rapid Practice Test

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Which of the following is a known precipitant of a hemolytic crisis in G6PD deficiency?
Correct Answer:
Sulfonamides
Explanation:
In G6PD deficiency the red blood cells can’t generate enough NADPH to keep glutathione in its reduced form, so they can’t effectively neutralize oxidative stress. When a drug or substance creates oxidative stress, hemoglobin is damaged and Heinz bodies form, leading to red cell destruction and a hemolytic crisis. Sulfonamides are a classic source of oxidative stress for RBCs, so they are the best answer. The other options are not reliable triggers of hemolysis in most G6PD variants at typical doses; acetaminophen and aspirin are not known for this effect, and vitamin C is not a standard precipitant in this context.

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