Pharmacology IV – Headache Therapeutics Practice Test

Which of the following describes a common adverse effect of onabotulinumtoxin A for migraine prophylaxis?

Neck pain and headache Severe hepatotoxicity Tremor and weight gain Seizures

Correct Answer:

Neck pain and headache

Explanation:

When using onabotulinumtoxin A for chronic migraine prevention, the side effects most often come from the local effect on nearby muscles where the injections are given. Injecting into pericranial and neck muscles can cause muscle soreness and temporary changes in muscle tone, so neck pain and headache are commonly reported after treatment. In contrast, severe hepatotoxicity, tremor with weight gain, or seizures are not typical adverse effects of this localized therapy. Therefore, neck pain and headache best describe a common adverse effect.

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