Schizophrenia And Psychotic Disorders Practice Test

Which metabolic pathway is associated with lamotrigine interactions according to the material?

CYP450 enzymes P-glycoprotein SLC transporters UGT enzymes

Correct Answer:

UGT enzymes

Explanation:

Lamotrigine is cleared mainly through glucuronidation by UDP-glucuronosyltransferase (UGT) enzymes, especially UGT1A4. This glucuronidation pathway is where most clinically relevant interactions occur—most notably with valproic acid, which inhibits UGT-mediated glucuronidation and raises lamotrigine levels, increasing the risk of serious rash. The CYP450 system, P-glycoprotein, and SLC transporters are not the primary routes for lamotrigine metabolism, so interactions via those pathways are less expected.

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