The Pitt Medical Terminology Practice Test

Second-generation antipsychotics, also called atypical antipsychotics, are designed to treat psychotic symptoms with fewer movement-related side effects than older drugs. They typically block dopamine D2 receptors but also strongly antagonize serotonin 5-HT2A receptors, which helps improve a broader range of symptoms, including some negative symptoms, while reducing extrapyramidal symptoms. Olanzapine is a classic example of this class. It combines D2 and 5-HT2A receptor antagonism to manage psychosis with a lower risk of motor-side effects compared with older medications like haloperidol or chlorpromazine, though it carries metabolic side effects such as weight gain and glucose issues. Haloperidol and chlorpromazine are traditional, first-generation antipsychotics with stronger D2 blockade and higher EPS risk. Lithium is a mood stabilizer, not an antipsychotic. So olanzapine fits the description of a second-generation antipsychotic.