PANCE Endocrinology Practice Test

Which is an absolute contraindication to testosterone therapy?

Controlled hypertension Prostate cancer Mild hyperlipidemia Age over 70

Correct Answer:

Mild hyperlipidemia

Explanation:

Testosterone therapy is avoided when there are cancers that could be driven by androgens. The clearest absolute contraindication is known or suspected prostate cancer, because testosterone can stimulate prostate tissue and potentially accelerate tumor growth. That makes prostate cancer the primary contraindication to start or continue therapy. Controlled hypertension, mild hyperlipidemia, and age over 70 are not by themselves absolute blockers to testosterone treatment. Hypertension can be managed and monitored; mild lipid abnormalities can be addressed with lifestyle changes or therapy; and age alone doesn’t disqualify treatment, though all risks and benefits should be weighed in older patients.

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