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COMSAE Comprehensive Osteopathic Medical Self-Assessment Exam

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A 22-year-old male of Mediterranean descent presents with fatigue, jaundice, and dark urine after being treated with a sulfonamide antibiotic for a urinary tract infection. A complete blood count reveals normocytic anemia, and a peripheral smear shows Heinz bodies and bite cells. This presentation is most characteristic of a deficiency in which of the following enzymes?
Correct Answer:
Glucose-6-phosphate dehydrogenase

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