Systems Pathology Exam 1 Practice

Which glands are commonly involved in MEN1?

Pituitary, adrenal cortex, parathyroid Thyroid, pancreas, adrenal cortex Pituitary, pancreas, parathyroid Adrenal medulla, pancreas, thyroid

Correct Answer:

Pituitary, pancreas, parathyroid

Explanation:

This question tests the organ triad most characteristic of MEN1. MEN1 predisposes to tumors in three endocrine glands: parathyroids, pituitary, and pancreatic islet cells. Among these, parathyroid involvement is the most common and often presents first as hyperparathyroidism from gland hyperplasia. Pituitary adenomas are also frequent, typically prolactin-secreting but can involve other pituitary hormones. Pancreatic neuroendocrine tumors arise from the islet cells, with gastrinomas, insulinomas, and other neuroendocrine tumors observed in MEN1. Other glands listed in the options—such as the thyroid or adrenal glands—are not the hallmark targets of MEN1 (distinct MEN syndromes involve those tissues). Hence, pituitary, pancreas, and parathyroid best fit the MEN1 pattern.

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