Certified Wound Ostomy Nurse

The stratum granulosum is the epidermal layer responsible for the secretion of ceramides. This layer, which is situated above the stratum spinosum and below the stratum corneum, plays a critical role in the process of keratinization. Within the stratum granulosum, keratinocytes begin to lose their nuclei and organelles while producing keratohyalin granules and lamellar bodies, which contain ceramides and other lipids. Ceramides are essential for maintaining the skin barrier function because they help to form the lipid matrix that interlocks with the keratin fibers from the keratinocytes, promoting hydration and preventing transepidermal water loss. The balance of ceramides in the skin is vital for overall skin health, making the stratum granulosum a key layer in skin physiology and barrier function.