Certified Specialist In Oncology Nutrition (CSO) Practice Exam

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Which drug is used as an adjunct antiemetic due to its anxiolytic effects?
Correct Answer:
Lorazepam
Explanation:
Anxiety can drive or worsen nausea and vomiting, especially anticipatory nausea before chemotherapy. The drug most fitting as an adjunct antiemetic due to anxiolytic effects is a benzodiazepine, which calms anxiety, can provide mild sedation, and may cause short-term amnesia. This helps break the cycle of anticipatory nausea and improves overall control of symptoms when used with standard antiemetics. The other choices work through different mechanisms that don’t address anxiety: metoclopramide acts mainly as a dopamine receptor antagonist with prokinetic effects; promethazine is an antihistamine with sedative properties but not anxiolysis; dexamethasone has antiemetic effects via anti-inflammatory pathways but lacks anxiolytic action.

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