Therapy Radiopharmaceuticals Practice Test

Which brand names are associated with Y-90 microspheres?

Sir-Spheres and Thera-Spheres Sir-Spheres Thera-Spheres Zevalin

Correct Answer:

Sir-Spheres and Thera-Spheres

Explanation:

The concept here is that Y-90 microspheres used for targeted liver therapy come under two well-known brand names: SIR-Spheres and TheraSphere. SIR-Spheres are resin-based microspheres, while TheraSphere are glass-based microspheres. Both are delivered via the hepatic artery to lodge in tumor vessels and deliver localized beta radiation, but they come from different manufacturers and have different physical forms. Zevalin, by contrast, is a Y-90 radiolabeled antibody used for lymphoma, not a microsphere, so it isn’t a brand name for Y-90 microspheres.

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