CMSA Diploma In Anaesthesia DA(SA) Practice Questions - Diploma In Anaesthesia Of The College Of Anaesthetists Of South Africa Exam

Ketamine produces a state of 'dissociative anaesthesia'. What is its primary central molecular mechanism of action?

Potentiation of gamma-aminobutyric acid type A (GABAA) receptors Agonism at central alpha-2 adrenergic receptors Non-competitive antagonism of N-methyl-D-aspartate (NMDA) receptors Competitive inhibition of voltage-gated sodium channels

Correct Answer:

Non-competitive antagonism of N-methyl-D-aspartate (NMDA) receptors

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