FC Psych(SA) Part II Practice Questions - Fellowship Of The College Of Psychiatrists Of South Africa - Part II Exam

What is the standard clinical definition of treatment-resistant depression (TRD) in adult psychiatric practice?

Failure to respond to at least two adequate trials of different antidepressant classes at adequate doses and duration Failure to respond to a single 4-week trial of a selective serotonin reuptake inhibitor (SSRI) Persistence of depressive symptoms despite psychotherapy alone for 6 months Failure to achieve full symptom remission following low-dose tricyclic antidepressant monotherapy

Correct Answer:

Failure to respond to at least two adequate trials of different antidepressant classes at adequate doses and duration

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