General Knowledge Pathophysiology Practice Test

What is the samprapti (pathogenesis) of grudrasi?

Kapha vitiation in the stomach Majja gata vata in sciatic nerve Pitta accumulation in the liver Rakta dushti in the heart

Correct Answer:

Majja gata vata in sciatic nerve

Explanation:

Grudrasi is understood as a vataja disorder that affects the nervous system, specifically the pathways along the sciatic nerve. When vata matures or vitiates and travels into the majja dhatu (nerve tissue), it lodges there and travels along the nerve channels to the sciatic nerve. This majja gata vata produces the characteristic radicular pain, numbness, and weakness down the leg that radiates along the sciatic nerve. So the samprapti centers on vata vitiation that has entered majja and localized to the sciatic nerve, causing the painful, neuropathic pattern seen in grudrasi. The other options describe dosha or tissue involvement in organs or systems not aligned with nerve-driven radicular pain, which is why they’re less appropriate.

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