Anesthesia Board Practice Questions - Saudi Board Anesthesia Final Written Exam

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What is the primary mechanism of action of intravenous lipid emulsion (ILE) in the treatment of local anesthetic systemic toxicity (LAST)?

Direct antagonism of voltage-gated sodium channels Creation of a lipid sink that extracts lipophilic local anesthetics from cardiac tissue Enzymatic degradation of bupivacaine in the plasma Up-regulation of beta-adrenergic receptors in the myocardium

Correct Answer:

Creation of a lipid sink that extracts lipophilic local anesthetics from cardiac tissue

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