Arab Board Oncology Part 1 Practice Questions - Arab Board Medical Oncology Primary (Part 1) Written Examination - الامتحان الأولي لاختصاص طب الأورام (ABHS) Exam

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What is the primary mechanism by which approximately 85% to 90% of human malignant tumors maintain telomere length to achieve replicative immortality?

Alternative lengthening of telomeres (ALT) via homologous recombination Reactivation or transcriptional upregulation of telomerase reverse transcriptase (TERT) Constitutive activation of shelterin complex degradation Hypermethylation of the entire telomeric TTAGGG hexamer repeat array

Correct Answer:

Reactivation or transcriptional upregulation of telomerase reverse transcriptase (TERT)

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