Arab Board Urology Final Written Practice Questions - Arab Board Of Health Specializations Urology Final Written Examination Exam

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In a patient presenting with newly diagnosed, high-volume metastatic Hormone-Sensitive Prostate Cancer (mHSPC) per CHAARTED criteria, what is the guideline-recommended first-line standard of care systemic therapy?

Androgen Deprivation Therapy (ADT) combined with an Androgen Receptor Pathway Inhibitor (ARPI, e.g., enzalutamide, apalutamide, or abiraterone) OR triplet therapy (ADT + docetaxel + darolutamide/abiraterone) ADT monotherapy (LHRH agonist alone) with delayed treatment until symptoms develop First-line single-agent Cabazitaxel chemotherapy without ADT Immediate bilateral radical nephrectomy and pelvic exenteration

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