DABT Practice Questions - DABT Diplomate, American Board Of Toxicology Exam

Which of the following best describes first-pass metabolism?

Metabolism that occurs exclusively in the kidneys before excretion The initial metabolism of an orally administered substance in the gut wall and liver before reaching systemic circulation Metabolism that occurs during the first hour after intravenous administration The process of Phase I metabolism preceding Phase II metabolism

Correct Answer:

The initial metabolism of an orally administered substance in the gut wall and liver before reaching systemic circulation

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