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UCP2.04 Bad Blood Practice Test

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In the context of NSAID action, which molecule acts as a mediator in inflammation that is reduced by COX inhibition?
Correct Answer:
Prostaglandins
Explanation:
Prostaglandins are the inflammatory mediators produced from arachidonic acid by cyclooxygenase enzymes. NSAIDs work by inhibiting COX, so the production of prostaglandins drops. Since prostaglandins drive vasodilation, increased vascular permeability, and sensitization of pain nerves, their reduction explains the anti-inflammatory, analgesic, and fever-reducing effects of NSAIDs. Other mediators like cytokines, leukotrienes, and histamines come from different pathways and aren’t directly controlled by COX inhibition, so they’re not the primary target here.

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