AALAS Laboratory Animal Technician (LAT) Practice Test

How is an animal's antibody titer raised further after the initial injection of antigen?

Exposed to the disease. The animal is given a booster injection. The animal is given an antibiotic. The antibody titer cannot be raised after the initial injection.

Correct Answer:

The animal is given a booster injection.

Explanation:

After the first exposure to an antigen, the immune system creates memory B cells that persist over time. When a booster injection is given, these memory cells are quickly re-stimulated and produce a larger amount of antibody, often with higher affinity, leading to a higher antibody titer in the blood. This is the secondary immune response, which is faster and stronger than the initial response. Exposing the animal to disease is not a controlled or safe way to raise titers, and antibiotics do not stimulate antibody production. It’s incorrect to say titers cannot be raised after the initial injection—the booster is exactly what raises them by reactivating the immune memory.

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