Adverse Effects Of Blood Transfusion Practice Test

To prevent an anaphylactic transfusion reaction in an IgA-deficient recipient, which strategy is recommended?

Washed red blood cells Fresh frozen plasma Platelet concentrates Cryoprecipitate

Correct Answer:

Washed red blood cells

Explanation:

In IgA-deficient patients who have anti-IgA antibodies, transfusing donor IgA can trigger a severe anaphylactic reaction. The most effective way to prevent this is to minimize IgA exposure by removing donor plasma from the transfused product. Washed red blood cells have the plasma removed, leaving essentially IgA-free red cells for transfusion. In contrast, fresh frozen plasma, platelet concentrates, and cryoprecipitate all contain donor plasma and can introduce IgA, raising the risk of an anaphylactic reaction. Therefore, washing the red cells to remove plasma is the best preventive strategy.

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