AP US History Practice Questions - AP United States History (APUSH) Exam

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Which of the following most directly explains the catastrophic decline of Native American populations in the century after 1492?

The spread of Old World diseases such as smallpox to which Native peoples had no immunity Mass migration of Native peoples back to Asia A prolonged ice age that destroyed Native agriculture Voluntary conversion that ended traditional ways of life

Correct Answer:

The spread of Old World diseases such as smallpox to which Native peoples had no immunity

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