Step 2 CK First Aid Rapid Practice Test

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The initial therapy for Kawasaki disease to reduce inflammation and prevent coronary aneurysms includes which of the following?
Correct Answer:
IVIG plus high-dose aspirin
Explanation:
Reducing inflammation quickly to protect the coronary arteries is the goal in Kawasaki disease. The best initial therapy is giving intravenous immunoglobulin in a single high-dose infusion together with high-dose aspirin. IVIG dampens the immune attack on the vessel walls, substantially lowering the risk of coronary artery aneurysms. High-dose aspirin helps control inflammation and fever and provides antiplatelet effect to prevent thrombosis if aneurysms develop. After fever subsides, aspirin is typically continued at a low, antiplatelet dose for a period determined by coronary findings. Antibiotics alone won’t address the vasculitis, corticosteroids alone aren’t first-line for aneurysm prevention, and doing nothing would allow ongoing vascular inflammation SAMPLEand higher aneurysm risk.

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