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PMLS 2 Comprehensive Practice Test

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The greatest antigen-antibody reaction occurs under which transfusion circumstance?
Correct Answer:
A person with type O blood is given type A blood.
Explanation:
The main idea is that transfusion reactions happen when antibodies in the recipient attack antigens on the donor’s red blood cells. In the ABO system, type O individuals have antibodies against both A and B antigens in their plasma. If a type O recipient receives type A blood, the anti-A antibodies in the recipient will bind to the A antigens on the donor red cells. This triggers strong agglutination and hemolysis, producing the largest immune response. In the other scenarios, the donor cells either lack the target antigens or the recipient lacks antibodies against those antigens, so the reaction is much less pronounced.

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