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The ALK mutation in NSCLC stands for:
Correct Answer:
Anaplastic lymphoma kinase
Explanation:
The main idea is the exact name behind the acronym ALK. It stands for Anaplastic lymphoma kinase, a receptor tyrosine kinase that was first described in association with anaplastic large cell lymphoma. In NSCLC, rearrangements involving this gene produce a constantly active kinase that helps drive cancer growth, which is why ALK inhibitors are an important targeted therapy. The other possible expansions don’t match the established gene name—leukemia, lymphoid, or adenosine kinase refer to different proteins or contexts.

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