Clayton’s Basic Pharmacology For Nurses Practice Exam

Teratogenic reaction is defined as which of the following?

Adverse effect. Idiosyncratic reaction. Tolerance. Teratogenic reaction.

Correct Answer:

Teratogenic reaction.

Explanation:

Teratogenic effects involve birth defects or developmental problems in a fetus caused by exposure to a drug or chemical during pregnancy, especially during early organ formation. A teratogenic reaction, then, is a reaction that produces congenital anomalies in the developing fetus due to such exposure. This is distinct from a general adverse effect (any undesired effect that may occur in the mother or fetus but isn’t specifically fetal development–related), from an idiosyncratic reaction (an unpredictable, unusual response), and from tolerance (a diminished effect with repeated dosing). Teratogenic risk depends on timing and dose, with examples including drugs like thalidomide, isotretinoin, or substances like alcohol causing fetal harm when exposure occurs in pregnancy.

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