ABPath Molecular Genetic Pathology Practice Questions - American Board Of Pathology Molecular Genetic Pathology Subspecialty Certification Examination Exam

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Loss of which mismatch repair protein is most commonly associated with sporadic colorectal cancers exhibiting microsatellite instability?

MSH2 MSH6 MLH1 (via promoter hypermethylation) PMS2

Correct Answer:

MLH1 (via promoter hypermethylation)

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