Título De Especialista Em Anestesiologia (SBA AMB) Practice Questions - TEA - Título De Especialista Em Anestesiologia (Sociedade Brasileira De Anestesiologia AMB) Exam

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What is the biochemical mechanism responsible for the transient adrenocortical suppression observed following a single induction dose of etomidate?

Reversible concentration-dependent inhibition of the mitochondrial enzyme 11-beta-hydroxylase (CYP11B1) Competitive antagonism of adrenocorticotropic hormone (ACTH) receptors on the adrenal cortex Direct necrotic cytotoxicity to the zona fasciculata cells of the adrenal gland Irreversible blockade of cholesterol side-chain cleavage enzyme (CYP11A1)

Correct Answer:

Reversible concentration-dependent inhibition of the mitochondrial enzyme 11-beta-hydroxylase (CYP11B1)

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